Jaya Ram Simkhada, Ph.D.

Jaya Ram Simkhada, Ph.D.: CFFN Executive Member (2013-2015)

Jaya Ram Simkhada holds a Ph.D. degree in Pharmacy from Chosun University of South Korea. He is experienced as a Post-doctor and a Research Professor in the field of microbiology, protein biochemistry and cancer biology. He has also served as a principal in a government higher secondary school, and as a lecturer in various colleges (affiliated to Tribhuvan University) of Nepal. He has a strong track record and scientific accomplishments, which can be reflected by his several research articles published in the index journals. He has also presented papers/posters in several international conferences.

Publications:

  1. YH Choi, SS Cho, JR Simkhada , CN Seong, HJ Lee, HS Moon, JC Yoo. Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vacomycin-resistant enterococci (VRE) strains from Korean Hospitals. Afr. J. Biotechnol., 12(2013)2249-2253
  2. JR Simkhada, HY Yoo, DH Park, YH Choi, HJ Lee, SW Kim, JC Yoo. An ammonium sulfate sensitive endoxylanase produced by Streptomyces. Bioprocess Biosyst. Eng., 36(2013)819-825
  3. JR Simkhada, HY Yoo, YH Choi, SW Kim, JC Yoo. An extremely alkaline novel xylanase from a newly isolated Streptomyces strain cultivated in corncob medium. Appl. Biochem. Biotechnol. 168(2012)2017-27
  4. YH Choi, SS Cho, JR Simkhada, JC Yoo. A novel thermotolerant and acidotolerant peptide produced by a Bacillus strain newly isolated from a fermented food (kimchi) shows activity against multidrug-resistant bacteria. Int. J. Antimicrob. Agents, 40(2012)80-83
  5. P Mander, SS Cho, JR Simkhada, YH Choi, DJ Park, JC Yoo. An organic solvent-tolerant lipase from Streptomyces sp. CS133 for enzymatic transesterification of vegetable oils in organic media. Process Biochem. , 47(2012)635-642)
  6. P Mander, SS Cho, JR Simkhada, YH Choi, DJ Park, JW Ha, JC Yoo. An organic solvent-tolerant alkaline lipase from Streptomyces sp. CS268 and its application in biodiesel production. Biotechnol. Bioprocess Eng. 17(2012)67-75
  7. JR Simkhada, SS Cho, P Mander, YH Choi, JH Lee, JC Yoo. Purification, biochemical characterization and antithrombotic effect of a novel Streptomyces enzyme on carrageenan-induced mice tail thrombosis model. Thromb. Res. 129 (2012) 176-182
  8. JR Simkhada, HY Yoo, SS Cho, YH Choi, SW Kim, DH Park, JC Yoo. A novel cold-adapted lipase, LP28, from a mesophilic Streptomyces strain. Bioprocess Biosyst. Eng. 35(2012)217-225
  9. SS Cho, DJ Park, JR Simkhada, JH Hong, JK Sohng, OH Lee, JC Yoo. A neutral lipase applicable in biodiesel production from a newly isolated Streptomyces sp. CS326. Bioprocess Biosyst. Eng. (2012)227-234
  10. SS Cho, YH Choi, JR Simkhada, P Mander, DJ Park, JC Yoo. A newly isolated Streptomyces sp. CS392 producing three anti-microbial compounds. Bioprocess Biosyst. Eng. (2012)247-254
  11. P Mander, SS Cho, JR Simkhada, YH Choi, JC Yoo. A low molecular weight chymotrypsin-like novel fibrinolytic enzyme from Streptomyces sp. CS624. Process Biochem. , 46(2011)1449-1455)
  12. H.Y Yoo1, JR Simkhada1, SS Cho, DH Park, SW Kim, CN Seong, JC Yoo. A novel alkaline lipase from Ralstonia with potential application in biodiesel production. Bioresour. Technol. , 102(2011)6104-6111
    1equal contribution
  13. JR Simkhada, SS Cho, SJ Park, P Mander, YH Choi, JH Lee, JC Yoo. An oxidant- and organic solvent-resistant alkaline metalloprotease from Streptomyces olivochromogenes. Appl. Biochem. Biotechnol. 162(2010)1457-1470
  14. JR Simkhada, SS Cho, HS Choi, SW Kim, HC Lee, JK Sohng, JC Yoo. A new thermolabile alkaline phospholipase D from Streptomyces sp. CS628. Biotechnol. Bioprocess Eng. 15(2010)595-610
  15. JR Simkhada, P Mander, SS Cho, JC Yoo. A novel fibrinolytic protease from Streptomyces sp. CS684. Process Biochem. 45 (2010) 88-93
  16. SH Kim, SS Cho, JR Simkhada, SJ Park, HJ Lee, TS Kim, JC Yoo. Effects and action mechanism of Diospyros kaki on the differentiation of human leukemia HL-60 cells. Oncol. Rep., 23 (2010) 89-95
  17. P Mander, JR Simkhada, SS Cho, SJ Park, HS Choi, HC Lee, JK Sohng, JC Yoo. A novel phospholipase D from Streptomyces tendae, possessing only hydrolytic activity. Arch. Pharm. Res., 32 (2009) 1461–1467
  18. SH Kim, SS Cho, JR Simkhada, HJ Lee, SW Kim, TS Kim, JC Yoo. Enhancement of 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced HL-60 leukemia cell differentiation by Panax ginseng. Biosci. Biotechnol. Biochem., 73 (2009) 1048–1053
  19. SS Cho, JK Sohng, HJ Lee, SJ Park, JR Simkhada, JC Yoo. Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by high performance liquid chromatography. Arch. Pharm. Res., 32 (2009) 333–338
  20. HJ Lee, SS Cho, JR Simkhada, JC Yoo. Monoclonal antibody production and immunochemical detection of polyether antibiotics. Arch. Pharm. Res., 32 (2009) 435–439
  21. JR Simkhada, HJ Lee, SY Jang, SS Cho, EJ Park, JK Sohng, JC Yoo. A novel alkalo-and thermo-stable phospholipase D from Streptomyces olivochromogenes. Biotechnol. Lett., 31 (2009) 429–435
  22. JR Simkhada , HJ Lee , SY Jang, JH Kim, HC Lee, JK Sohng, JC Yoo. A novel low molecular weight phospholipase D from Streptomyces sp. CS684. Bioresour. Technol., 100 (2009) 1388–1393
  23. JK Sohng, T Yamaguchi, CN Seong, KS Baik, SC Park, HJ Lee, SY Jang, JR Simkhada, JC Yoo. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Arch. Pharm. Res., 31 (2008)1339–1345
  24. JR Simkhada, SS Cho, HJ Lee, JC Yoo. Purification and biochemical properties of phospholipase D (PLD57) produced by Streptomyces sp. CS57. Arch. Pharm. Res., 30 (2007)1302–1308

Selected poster/paper presentations:

  • JC Yoo and JR Simkhada. Purification and biochemical characterization of a thermostable xylanase from Korea soil bacteria. 2012 KSBB Spring Meeting & International Symposium, Changwon Exhibition Convention Center, Republic of Korea, April 11-13, 2012.
  • JR Simkhada, YH Choi, SS Cho, P Mander, SW Kim, JC Yoo. An organic solvent, detergent and oxidant stable metalloprotease from Streptomyces sp. CS528. ASEAN-Korean Symposium and Workshop on Biorefinery Technology, Mercure Convention Center, Jakarta, Indonesia, Feb 18-20, 2010.
  • SY Jang, JR Simkhada, JC Yoo. Monoclonal antibody production and immunochemical detection of polyether antibiotics. 7th International symposium on Advanced Environmental Monitoring, East-West Center Honolulu, HI, USA, Feb 24–29, 2008.
  • JR Simkhada and JC Yoo. A broad-spectrum extracellular protease from Streptomyces sp. CS684. 18th annual Queenstown molecular biology meeting, Queenstown, New Zealand, Sept 2–4, 2008.

Scholarships and Awards:

  • Research Professor Fellowship from Brain Korea-21, Chosun University, March 2011 to Feb 2012 • Post-Doctoral Fellowship from Brain Korea-21, Chosun University, March 2010 to Dec 2010
  • Full scholarship for Ph.D. study from Chosun University, Feb 2006 to Feb 2010.

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